منابع مشابه
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“Targeting signs of aging”. It sounds more like a punch-line of a TV commercial, than a consequence of fundamental science. But as we observed recently, it might actually be possible to achieve just that, using a prospectively designed FOXO4-p53 interfering peptide that targets so-called “senescent” cells [1]. More research is needed to fully assess its true translational potential and whether ...
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ophthalmic equipment, including surgical instruments and diagnostic devices, can be compared to the maintenance of a motor vehicle, something many of us understand well. If you had a car, would you drive it until the fuel runs out or until a tyre punctures, and then abandon it to buy a new car? Of course not. However, many eye care units purchase (or receive as a donation) expensive and delicat...
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Episodic memory and working memory decline with advancing age. Nevertheless, large-scale population-based studies document well-preserved memory functioning in some older individuals. The influential ‘reserve’ notion holds that individual differences in brain characteristics or in the manner people process tasks allow some individuals to cope better than others with brain pathology and hence sh...
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Neuroimaging studies of the aging brain provide support that the strongest predictor of preserved memory and cognition in older age is brain maintenance, or relative lack of brain pathology. Evidence for brain maintenance comes from different levels of examination, but up to now relatively few studies have used a longitudinal design. Examining factors that promote brain maintenance in aging is ...
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With the evolution of technology, the maintenance of sophisticated systems is of concern for system engineers and system designers. The maintenance cost of the system depends in general on the replacement and repair policies. The system replacement may be in a strictly periodic fashion or on a random basis depending upon the maintenance policy. At failure, the repair of the system may be perfor...
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ژورنال
عنوان ژورنال: Current Opinion in Physiology
سال: 2018
ISSN: 2468-8673
DOI: 10.1016/j.cophys.2018.05.007